GHRH (Growth Hormone Releasing Hormone) Peptide
Growth Hormone Releasing Hormone is commonly referred to as GRF (Growth Hormone Releasing Factor) or GHRH 1-44 because it is a peptide of 44 amino acids. Research studies have shown that in most species GRF (1-44) stimulates the release and synthesis of growth hormone. GRF is synthesized by neurons in the arcuate nucleus of the hypothalamus. After being released into the pituitary portal circulation, it stimulates GH release by the somatotrophs in the pituitary gland. Endogenous GHRH (1-44) has a very short active life, but is released from the hypothalamus before traveling a very short distance to the anterior pituitary, where GH is released. In contrast, exogenous peptides are typically supplied exogenously through one of several types of injection, and must circulate prior to reaching the pituitary and activating the GH-storing-and-releasing cells called somatotrophs. Research studies have shown that GHRH helps stimulate the release and synthesis of growth hormone. Research has also shown that It helps promotes slow-wave sleep. GHRH is synthesized by neurons in the arcuate nucleus of the hypothalamus. GHRH stimulates GH production and release by binding to the GHRH Receptor GRFR on cells.