GRF (1-44) 2mg

$29.50

The primary function of GRF 1-44 is to stimulate growth hormones release via the pituitary gland. GRF 1-44 contains 44 amino acids. The hormone is secreted in the arcate nucleus of the hypothalamus. It is hypothesized that GRF 1-44 may enhance IGF-1 release, immune functions and sleep. Upon release into the pituitary portal circulation, GRF 1-44 promotes growth hormone biosynthesis and release from the somatotrophs. By negative feedback inhibition, the compound influence growth hormone neuroendocrine axis and release of somatostatin. The release of GH is dependent on a cAMP-dependent pathway although in some instances the production may go through the phospholipase C pathway among other pathways. The cyclic AMP dependent pathway is initiated when the receptors changes its conformation, this in turn causes the activation of G –alpha sub unit of the G-protein complex. When the G-alpha sub unit is activated, it stimulates the adenylyl cyclase, this is membrane bound, and it increases the cyclic AMP.

GRF 1-44 release to the bloodstream stimulates the production of growth hormone from the somatotrophs in the pituitary gland. The hormone is an endogenous hormone and it is essential in accentuating the release of GH and inhibiting the activities of somatostatin. Recent studies indicate that the hormone is vital in promoting slow wave sleep; the receptors are specific to the hormone and function effectively when in conjunction with Ghrelin. The GRF 1-44 has a very short half life after its release from the anterior lobe of the pituitary gland. Studies have shown that GRF 1-44plays a very crucial role in the production of growth hormone. GHRH accentuates the production of GH by binding to GHRH receptor GRFR on the cells .

 

GRF 1-44 Chemical Profile

 

CAS: 90599-39-6 

Formula: C215H358N72O66S1

Molecular weight: 5039.65 

Peptide purity: > 99.0% 

Chain: H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH2

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Packing Strength 1 x Vial
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